Clinical

2012

 

Real-life effect of classical homeopathy in the treatment of allergies: A multicenter prospective observational study.

Gründling C, Schimetta W, Frass M.

Wien Klin Wochenschr. 2012 Jan;124(1-2):11-7

ABSTRACT: In this prospective multicenter observational study homeopathic treatment seems to improve symptoms of patients. Results show that there is a potential for enhancing therapeutic measures and reducing healthcare cost, but it is impossible to draw conclusions as to the efficacy of homeopathic treatment per se.

 

Homeopathic medicines substantially reduce the need for clotting factor concentrates in haemophilia patients: results of a blinded placebo controlled cross over trial.

Kundu T, Shaikh A, Kutty A, Nalvade A, Kulkarni S, Kulkarni R, Ghosh K.

Homeopathy. 2012 Jan;101(1):38-43.

ABSTRACT: To investigate the effectiveness of individualized homeopathic medicines in reducing the requirement of factor concentrates in haemophilia patients (PWH), in a single blind placebo controlled cross over trial 28 persons with PWH received standard management with placebo for 1 year and active homeopathic treatment in the subsequent year with the same conventional management. Individualized homeopathic medicines may have an important supportive role in the management of PWH

 

Homeopathic Treatment of Migraine in Children: Results of a Prospective, Multicenter, Observational Study.

Danno K, Colas A, Masson JL, Bordet MF.

J Altern Complement Med. 2012 Sep 14.

ABSTRACT: The study evaluated the effectiveness of homeopathic medicines for the prevention and treatment of migraine in children. Prescriptions were individualized for each patient. A significant decrease in the frequency, severity, and duration of migraine attacks was observed.

 

 

Antiresorptive drugs (bisphosphonates), atypical fractures and rebound effect: new evidence of similitude.

Teixeira MZ.

Homeopathy. 2012 Oct;101(4):231-42.

ABSTRACT:  The study highlights the rebound effect of antiresorptive drugs and notes the similarity with the primary and secondary opposite action of the organism taught by Hahnemann

 

Individualized homeopathy in a group of Egyptian asthmatic children.

Shafei HF, AbdelDayem SM, Mohamed NH.

Homeopathy. 2012 Oct;101(4):224-30.

ABSTRACT: In a prospective observational longitudinal study the effects of individualised homeopathic medicines were assessed in 30 children with asthma as an adjunct to conventional treatment.

There were clinically relevant and statistically significant changes in symptoms.

The study shows that homeopathic medicines improve severity of asthma in children. Controlled studies should be conducted.


Homeopathy in paediatric atopic diseases: long-term results in children with atopic dermatitis.

Rossi E, Bartoli P, Bianchi A, Da Frè M.

Homeopathy. 2012 Jan;101(1):13-20.

ABSTRACT: Data derive from an observational longitudinal study carried out on 213 children (38.6%) with atopic diseases (AD) out of 551 children consecutively examined from September 1998 to December 2008 and treated with homeopathy at the Homeopathic Clinic of Lucca (Italy). Preliminary results seem to confirm a positive therapeutic effect of homeopathy in atopic children.

 

 

2011

Classical homeopathy in the treatment of cancer patients--a prospective observational study of two independent cohorts.

Rostock M, Naumann J, Guethlin C, Guenther L, Bartsch HH, Walach H.

Tumour Biology Center at Albert Ludwig's University Freiburg, Germany. matthias.rostock@usz.ch

ABSTRACT: Many cancer patients seek homeopathy as a complementary therapy. It has rarely been studied systematically, whether homeopathic care is of benefit for cancer patients.

 

 

Homeopathic Individualized Q-Potencies versus Fluoxetine for Moderate to Severe Depression: Double-Blind, Randomized Non-Inferiority Trial.

 

Adler UC, Paiva NM, Cesar AT, Adler MS, Molina A, Padula AE, Calil HM.

 

Evid Based Complement Alternat Med. 2011;2011:520182.

 

ABSTRACT: This Double-Blind, Randomized Non-Inferiority Trial shows the non-inferiority of individualized homeopathic Q-potencies as compared to fluoxetine in acute treatment of outpatients with moderate to severe depression.

 

Characteristics associated with use of homeopathic drugs for psychiatric symptoms in the general population.

 Grolleau A, Bégaud B, Verdoux H.

Eur Psychiatry. 2011 Dec 6.

ABSTRACT: The study shows that the use of homeopathic treatment for psychiatric symptoms was reported by 1.3% of persons and the treatment for psychiatric symptoms appears to be used mainly to reduce anxiety symptoms in the general population.

 

 

Management of distress during climacteric years by homeopathic therapy.

 

Nayak C, Singh V, Singh K, Singh H, Gupta J, Lamba CD, Sharma A, Sharma B, Indira B, Bhuvaneshwari S, Bindra SK, Luxmi KS.

 

J Altern Complement Med. 2011 Nov;17(11):1037-42.

 

ABSTRACT: In this study homeopathic therapy with the use of the 'simillimum' was found to be useful in relieving menopausal distressing symptoms. Serum levels of cholesterol, triglycerides, and very-low-density lipoprotein decreased significantly

 

 

Short-Term Effects of Repeated Olfactory Administration of Homeopathic Sulphur or Pulsatilla on Electroencephalographic Alpha Power in Healthy Young Adults

 

Bell IR, Brooks AJ, Howerter A, Jackson N, Schwartz GE.

 

Homeopathy. 2011 Oct;100(4):203-11. doi: 10.1016/j.homp.2011.06.005.

 

ABSTRACT: College student volunteers underwent a series of double-blind sessions during which they repeatedly sniffed the remedies Sulfur or Pulsatilla. Mixed-effect models revealed significant main effects for remedy type in both alpha bands. Authors conclude that EEG alpha offers an objective biomarker of remedy effects for future studies.

 

 

An exploratory study on scientific investigations in homeopathy using medical analyzer.

 

Mishra N, Muraleedharan KC, Paranjpe AS, Munta DK, Singh H, Nayak C.

 

J Altern Complement Med. 2011 Aug;17(8):705-10. doi: 10.1089/acm.2010.0334.

 

ABSTRACT: The study  shows that it is possible to record the response of homeopathic medicines on physiologic parameters of the autonomic nervous system such as heart rate variability and blood flow

 

2010

 Chronic primary insomnia: efficacy of homeopathic similimum

Naude´ DF, Stephanie Couchman IM, Maharaj A.

Department of Homoeopathy, Faculty of Health Sciences, Durban University of Technology

ABSTRACT:

Chronic primary insomnia is defined as difficulty in initiating or maintaining sleep or of non-restorative sleep that lasts for at least 1 month and causes significant distress or impairment in social, occupational or other important areas of functioning. The homeopathic simillimum is that remedy which most closely corresponds to the totality of symptoms; remedy selection is based on a full evaluation of the patient's physical, emotional and mental characteristics. AIM/PURPOSE: The purpose of this randomised, double-blind, placebo-controlled study was to evaluate the efficacy of homeopathic simillimum in the treatment of chronic primary insomnia.

METHOD:

30 participants were selected in accordance with DSM-IV TR (2000)(1) criterion 307.42 Primary Insomnia and then randomly divided between treatment and placebo groups. The measurement tools used were a Sleep Diary (SD) and the Sleep Impairment Index (SII).(2) After an initial consultation, 2 follow-up consultations at 2-week intervals took place. Homeopathic medication was prescribed at the first and second consultations. The SII was completed at each consultation and participants were instructed at the first consultation to start the SD.

RESULTS:

SD data revealed that verum treatment resulted in a significant increase in duration of sleep throughout the study, compared to the placebo treatment which resulted in no significant increase in duration of sleep. A significant improvement in SII summary scores and number of improved individual questions were found in the verum group, responses to all 11 questions having improved significantly upon completion of the study. An initial improvement occurred in the placebo group, but was not sustained. Comparison of results between the groups revealed a statistically significant difference.

CONCLUSION:

The homeopathic simillimum treatment of primary insomnia was effective, compared to placebo. Homeopathy is a viable treatment modality for this condition and further research is justified.

 

 

 2009

Low dose oral administration of cytokines for treatment of allergic asthma.

Gariboldi S, Palazzo M, Zanobbio L, Dusio GF, Mauro V, Solimene U, Cardani D, Mantovani M, Rumio C.

iMIL - italian Mucosal Immunity Laboratory, Department of Human Morphology and Biomedical Sciences Città Studi, Università degli Studi di Milano, via Mangiagalli 31, 20133 Milano, Italy.

ABSTRACT

Many inflammatory diseases are characterized by an imbalance among lymphocyte populations, in particular Th1, Th2 and the recently described Th17 cells. The Th1/Th2 imbalance is linked to many factors, but certainly the role of cytokines is essential. In Th2 diseases IL-4 expression is predominant, while Th1 pathologies are characterized by high expression of IFN-gamma and IL-12. Though today the therapeutical proposal for many inflammatory diseases aims to re-establish normal levels of Th1/Th2 cytokines, the pharmacological use of cytokines, which are very active molecules, is limited by the possible collateral effects. Therefore, our study aims to determine, in a murine model of allergic asthma, the possible therapeutic activity of low dose cytokines solutions, mechanically activated. We found that oral administration of low doses IL-12 plus IFN-gamma is able to solve the bronchial hyperresponsiveness condition of mice, establishing normal cytokine levels. The anti-asthma activity was confirmed by histological analysis of lungs and broncho-alveolar lavage fluid cell count. Serum ovalbumin-specific IgE was also significantly inhibited by treatment with low dose activated cytokines solution. These findings may suggest a novel approach to diseases which involve a Th1/Th2 imbalance.

 

Homeopathy as an effective treatment for low back pain

 

Witt, CM, Lüdtke R, Baur R, Willich SN.

Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany

ABSTRACT:

A prospective multi-centre observational study describes the details and effects of an individualized homeopathic treatment in patients with chronic low back pain in usual care. The results come from a sub-group analysis of patients suffering from low back pain that were part of a large prospective multi-centre observational study population carried out over an 8-year period. Consecutive patients beginning homeopathic treatment in primary care practices were evaluated over 2 years by using standardized questionnaires.
Diagnoses (ICD-9) and symptoms with severity, health-related quality of life (QoL), medical history, consultations, homeopathic and conventional treatments, and other health service use were recorded. The study included 129 adults, treated by 48 physicians. Nearly all the patients (91.3%) had been pretreated. The severity of the diagnoses and complaints showed marked and sustained improvements with large effect sizes (Cohen's d from 1.67 to 2.55) and quality of life improved accordingly. The use of conventional treatment and health services decreased markedly: the number of patients using low back pain-related drugs was half of the baseline.
The authors conclude that individualized homeopathic treatment represents an effective treatment for low back pain. It improves health-related quality of life and reduces the use of other healthcare services.

 

Homeopathic medicines for adverse effects of cancer treatments.

Kassab S, Cummings M, Berkovitz S, van Haselen R, Fisher P.

Royal London Homoeopathic Hospital, 60 Great Ormond Street, London, UK, WC1N 3HR

ABSTRACT:

BACKGROUND: Homeopathic medicines are used by patients with cancer, often alongside conventional treatment. Cancer treatments can cause considerable morbidity and one of the reasons patients use homeopathic medicines is to help with adverse effects.

OBJECTIVES: Evaluate effectiveness and safety of homeopathic medicines used to prevent or treat adverse effects of cancer treatments.

 

Homeopathic Individualized Q-potencies versus Fluoxetine for Moderate to Severe Depression

U.C. Adler. N.M.P. Paiva, A.T. Cesar, M.S. Adler, A.Molina, A.E. Padula, H.M. Calil

Faculdade de Medicina de Jundiaí, Homeopathy Graduation Programme, Department of Psychobiology, Universidade Federal de São Paulo

ABSTRACT:

Homeopathy is a complementary and integrative medicine used in depression, The aim of this study is to investigate the non-inferiority and tolerability of individualized homeopathic medicines [Quinquagintamillesmial (Q-potencies)] in acute depression, using fluoxetine as active control. Ninety-one outpatients with moderate to severe depression were assigned to receive an individualized homeopathic medicine or fluoxetine 20?mg?day?1 (up to 40?mg?day?1) in a prospective, randomized, double-blind double-dummy 8-week, single-center trial. Primary efficacy measure was the analysis of the mean change in the Montgomery & Åsberg Depression Rating Scale (MADRS) depression scores, using a non-inferiority test with margin of 1.45. Secondary efficacy outcomes were response and remission rates. Tolerability was assessed with the side effect rating scale of the Scandinavian Society of Psychopharmacology. Mean MADRS scores differences were not significant at the 4th (P = .654) and 8th weeks (P = .965) of treatment. Non-inferiority of homeopathy was indicated because the upper limit of the confidence interval (CI) for mean difference in MADRS change was less than the non-inferiority margin: mean differences (homeopathy-fluoxetine) were ?3.04 (95% CI ?6.95, 0.86) and ?2.4 (95% CI ?6.05, 0.77) at 4th and 8th week, respectively. There were no significant differences between the percentages of response or remission rates in both groups. Tolerability: there were no significant differences between the side effects rates, although a higher percentage of patients treated with fluoxetine reported troublesome side effects and there was a trend toward greater treatment interruption for adverse effects in the fluoxetine group. This study illustrates the feasibility of randomized controlled double-blind trials of homeopathy in depression and indicates the non-inferiority of individualized homeopathic Q-potencies as compared to fluoxetine in acute treatment of outpatients with moderate to severe depression.

 

 

The Efficacy of Ultramolecular Aqueous Dilutions on a Wheat Germination Model as a Function of Heat and Aging-Time

Maurizio Brizzi, Vittorio Elia, Grazia Trebbi, Daniele Nani, Maurizio Peruzzi, Lucietta Betti

ABSTRACT:

This study evaluates the effects of temperature and aging on the efficacy of As2O3 at the 45th decimal potency in a wheat germination model, compared against a control and potentized H2O 45×. Each treatment-temperature combination was tested on seeds (Triticum aestivum L.) of Pandas variety, using six Petri dishes (33 seeds/dish) per trial, performing eight trials. Seeds were pre-treated by poisoning with 0.1% As2O3 solution to reduce germination, to allow a better evaluation of homeopathic treatment effects. The outcome variable was the number of non-germinated seeds after 96?h. Temperature effect was investigated by heating each treatment in a water bath for 30?min (at 20, 40 or 70°C), or for 5?min (at 100°C), and that of aging by dividing experimental data, collected over a period of nearly five months, into two groups: early and late experiments. Results seem to show that the efficacy of As2O3 45× is unaltered at 20 and 40°C, increases at 70°C and decreases at 100°C. As regards aging, a notable difference was found between early trials, with no significant efficacy, and late trials, where As2O3 45× exhibits a repeated significant effect versus control, except at 100°C. A reduction in variability was observed for As2O3 45× at 20°C versus control, confirming the findings of previous work. The main conclusion suggested by this experiment is that the efficacy of As2O3 45× on wheat germination may be influenced by heating degree and seems to have an increasing trend as a function of aging.

 

 

2008:

Treating hot flushes in menopausal women with homeopathic treatment--results of an observational study.

Bordet MF, Colas A, Marijnen P, Masson J, Trichard M.

Homeopathy. 2008 Jan;97(1):10-5.

 ABSTRACT: Open, multi-national prospective, non-comparative observational study suggest that homeopathic treatment for hot flushes in menopausal women is effective. Authors conclude that  further studies including randomized controlled trials should be conducted.

 

Homeopathic practice in Intensive Care Units: objective semiology, symptom selection and a series of sepsis cases.

Teixeira MZ, Leal SM, Ceschin VM.

Homeopathy. 2008 Oct;97(4):206-13.

 

ABSTRACT: In view of the difficulty of practising homeopathy in Intensive Care Units (ICU), a protocol was developed to facilitate description of objective homeopathic symptoms appropriate for these situations

Examples of favorable results with individualized homeopathic treatments for a series of cases of Systemic Inflammatory Response Syndrome (sepsis) are described.

 

 

The 2005 meta-analysis of homeopathy: the importance of post-publication data.

Rutten AL, Stolper CF.

Homeopathy. 2008 Oct;97(4):169-77.

ABSTRACT:Authors observed a discrepancy between the outcome of a meta-analysis published in 1997 of 89 trials of homeopathy by Linde et al and an analysis of 110 trials by Shang et al published in 2005: opposite conclusions were reached.

Re-analysis of Shang’s post-publication data did not support the conclusion that homeopathy is a placebo effect. The conclusion that homeopathy is a placebo effect was not justified because of heterogeneity and lack of sensitivity analysis.

Finally the quality of homeopathic trials is better than of conventional trials, for all trials (p = 0.03) as well as for smaller trials (p = 0.003).

 

 

The conclusions on the effectiveness of homeopathy highly depend on the set of analyzed trials.

Lüdtke R, Rutten AL.

J Clin Epidemiol. 2008 Dec;61(12):1197-204.

ABSTRACT: It is performed an assessment of the Shang's published meta-analysis on homeopathic remedies. Conclusions are that Shang’s results are less definite than had been presented.

 

2005

Adjunctive homeopathic treatment in patients with severe sepsis: a randomized, double-blind, placebo-controlled trial in an intensive care unit.

Frass M, Linkesch M, Banyai S, Resch G, Dielacher C, Löbl T, Endler C, Haidvogl M, Muchitsch I, Schuster E.

Mortality in patients with severe sepsis remains high despite the development of several therapeutic strategies. The aim of this randomized, double-blind, placebo-controlled trial was to evaluate whether homeopathy is able to influence long-term outcome in critically ill patients suffering from severe sepsis.

 

Analysis of the capability of ultra-highly diluted glucose to increase glucose uptake in arsenite-stressed bacteria Escherichia coli.

Khuda-Bukhsh AR, DeA, Das D, Dutta S, Boujedaini N.

Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani

ABSTRACT: Whether ultra-highly diluted homeopathic remedies can affect living systems is questionable. Therefore, this study sees value in the analysis of whether homeopathically diluted glucose 30C has any effect on Escherichia coli exposed to arsenite stress.