Substances & Homeopatic Remedies

Acalypha indica

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J Ethnopharmacol. 1999 Nov 30;67(3):253-8. Related Articles, Links   
Post-coital antifertility activity of Acalypha indica L.
Hiremath SP, Rudresh K, Badami S, Patil SB, Patil SR.
Department of Chemistry, Gulbarga University, India.

Four successive solvent extracts of the whole plant Acalypha indica L. (Euphorbiaceae) were tested for post-coital antifertility activity in female albino rats. Of these, the petroleum ether and ethanol extracts were found to be most effective in causing significant anti-implantation activity. The antifertility activity was reversible on withdrawal of the treatment of the extracts. Both the extracts at 600 mg/kg body weight showed estrogenic activity. Histological studies of the uterus were carried out to confirm this estrogenic activity.

Ceylon Med J. 1994 Mar;39(1):46-7. Related Articles, Links  
Acalypha indica induced haemolysis in G6PD deficiency.
Lamabadusuriya SP, Jayantha UK.
Department of Paediatrics, Faculty of Medicine, Colombo.

Four patients who developed acute intravascular haemolysis after ingestion of a broth containing Acalypha indica (Sinhala: Kuppameniya) are reported. All four patients were found to have glucose-6-phosphate dehydrogenase deficiency. It is a common belief that ayurvedic medicines are free of side effects. Our report confirms again the fallacy of this belief.

Trop Doct. 1996 Jan;26(1):32. Related Articles, Links  
Acute intravascular haemolysis in glucose-6-phosphate dehydrogenase deficient patients following ingestion of herbal broth containing Acalypha indica.
Senanayake N, Sanmuganathan PS.

J Ethnopharmacol. 2004 Oct;94(2-3):267-73. Related Articles, Links  
Neutralization potential of Viper russelli russelli (Russell's viper) venom by ethanol leaf extract of Acalypha indica.
Shirwaikar A, Rajendran K, Bodla R, Kumar CD.
Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal, Karnataka, India. annieshirwaikar@yahoo.com

The study aims to examine the Viper russelli russelli venom neutralization potential of the ethanol leaf extract (250, 500 and 750 mg/kg) of Acalypha indica (Euphorbiaceae). Administration of the ethanol leaf extract at i.p. dose levels of 500 and 750 mg/kg significantly inhibited, in a dose dependent manner, the Viper russelli venom-induced lethality, haemorrhage, necrotizing and mast cell degranulation in rats and the cardiotoxic and neurotoxic effects in isolated frog tissue. Administration of the extract also significantly inhibited venom-induced lipid peroxidation in RBC, decreased GSH and catalase levels of rat kidney tissue. The observations confirmed that the ethanol leaf extract of Acalypha indica possesses potent snake venom neutralizing properties.

J Ethnopharmacol. 2002 Feb;79(2):249-51. Related Articles, Links  
Wound healing effects of Heliotropium indicum, Plumbago zeylanicum and Acalypha indica in rats.
Reddy JS, Rao PR, Reddy MS.
University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009 AP, India.

The ethanolic extracts of Heliotropium indicum, Plumbago zeylanicum and Acalypha indica were evaluated for their wound healing activity in rats. Wound healing activity was studied using excision and incision wound models in rats following topical application. Animals were divided into four groups with six in each group. Ten percent w/v extract of each plant was prepared in saline for topical application. H. indicum possesses better wound healing activity than P. zeylanicum and A. indica. Tensile strength results indicate better activity of H. indicum on remodeling phase of wound healing.