Requests: If you need specific information on this remedy - e.g. a proving or a case info on toxicology or whatsoever, please post a message in the Request area www.homeovision.org/forum/ so that all users may contribute.
Constituents: Constituents - The primary constituent is a yellow flavonoid, Euparin. It also contains eupatoriopicrin, sesquiterpene lactones , tannins, bitters, gum and resin.
Toxicology - The taste is astringent, aromatic and bitter. BoDD says that a potentially allergenic costunolide derivative has been isolated in gravelweed, but the sesquiterpene lactones, unlike many Asteracaceae, are very weakly phototoxic.Unable to find any designation of the plant as toxic. Certainly not on Veterinary databases.
Pharmacology - It is antilithic, diuretic, antirheumatic ( It promotes the excretion of uric acid ), promotes menstruation, and eases childbirth by its action on pelvic viscera.
It is indicated for urinary calculus, cystitis, dysuria, urethritis, prostatitis, rheumatism and gout.
The roots should be collected in the Autumn.
Dried rhizome and root: 2-4 grams or by decoction - used for period pain or sipped during labour.
Liquid extract: 1:1 in 25% alcohol, 2-4 mls.
Tincture: 1:5 in 40% alcohol, 1-2 mls.
The herb was a great favourite among many Native Americans.
The Cherokee not only used the plant as a medicine, but used a section of the stem to blow or spray medicine.
They used the root for gout, dropsy, rheumatism and as a diuretic. A compound decoction of the root was The root was also used a gynaecological aid, and an infusion of the root as a tonic during pregnancy.
Another use of the infusion of the root was as a wash ì after becoming sick from the odour of a corpse. used for difficult urination.
The Chippewa used the vapours from infusions of the plant tops as a cold remedy.
Flavonoid (eupatorin) 2 Volatile oil 2Resin.
Planta Med. 1998 Dec;64(8):683-5.
Cistifolin, an integrin-dependent cell adhesion blocker from the anti-rheumatic herbal drug, gravel root (rhizome of Eupatorium purpureum).
Department of Physiology and Pharmacology, University of Strathclyde, U.K.
During routine screening of medicinal plants for small molecular weight inhibitors of cell adhesion, the crude ethanolic extract of the anti-rheumatic herbal drug gravel root (rhizome of Eupatorium purpureum), was identified as a potent inhibitor of some beta 1 and beta 2 integrin-mediated cell adhesions. The active principle of gravel root has now been isolated and identified as 5-acetyl-6-hydroxy-2,3-dihydro-cis-2-isopropenyl-3- tiglinoyloxybenzofuran (1). Compound 1 inhibited integrin-dependent cell-cell and cell-protein interactions in vitro with EC50 values between 7-20 micrograms/ml. As with indomethacin, 1 administered orally two hours before induction of inflammation (in rat paw) by carrageenan inhibited oedema formation in a dose (10 and 50 mg/kg)-dependent manner. It appears that 1 has therapeutic potential for diseases where integrin adhesion molecules play a significant role.
Phytother Res. 2001 Dec;15(8):687-90.
Antiinflammatory activity of the antirheumatic herbal drug, gravel root (Eupatorium purpureum): further biological activities and constituents.
School of Chemical and Life Sciences, University of Greenwich, Wellington Street, Woolwich, London SE18 6PF, UK.
Previous reports from this laboratory revealed that cistifolin from the antirheumatic herbal drug, gravel root (rhizome of Eupatorium purpureum), showed activity both in in vitro and in vivo models of inflammation. Data are now presented to show that, in addition to the LFA-1 and other integrin-mediated leucocyte adhesions, cistifolin inhibits the Mac-1 (CD11b/CD18)-dependent monocyte adhesion to fibrinogen in a concentration-dependent manner. Further phytochemical analysis of the crude extract also led to the isolation of three known benzofurans, euparin, euparone, 6-hydroxy-3beta-methoxytrematone and a new benzofuran, 5-acetyl-6-hydroxy-2-(1-oxo-2-acetoxy-ethyl)-benzofuran. None of these compounds were active in suppressing integrin-mediated monocytic U937 cell adhesions in vitro.