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Constituents: Alanine. Alpha-linolenic acid. Aluminum. Arginine. Arsenic. Aspartic acid. Boron. Cadmium. Chlorine. Chromium. Cobalt. Copper. Cystine. Fiber. Glutamic acid. Glycine. Gold. Histidine. Iodine. Iron. Isoleucine. Juglone. Leucine. Linoleic acid. Lysine. Magnesium. Manganese. Mercury. Methionine. Molybdenum. Nickel. Oleic acid. Palmitic acid. Phenylalanine. Phosphorus. Potassium. PUFA. Rubidium. Selenium. Serine. Silicon. Sodium. Stearic acid. Strontium. Sulfur. Tannin. Threonine. Tin. Tryptophan. Tyrosine. Valine. Vanadium. Zinc. (USDA).
Toxicology: The leaves possess much the same properties as the black walnut. Butternut is a mild cathartic like rhubarb; it does not constipate and is often used as a habitual laxative, also for dysentery and hepatic congestions. It has been valued as one of the mildest laxatives given by nature as it doesn't cause nausea, irritation, or pain, and it doesn't impair the digestive function. The fruit when half-grown is made into pickles and when matured is a valuable article of diet. The bark is used for dyeing wool a dark brown colour but is inferior to that of the Black Walnut for this purpose. When first uncovered the inner bark is of a pure white, which becomes immediately on exposure a beautiful lemon colour. The tree's sweet sap is sometimes mixed with the sap of the Maple, Acer saccharinum , to make sugar and syrups. (Vermeulen’s Synoptic ll).
Constituents---A bitter extractive, a large proportion of oily matter, a volatilizable acid and juglandic acid. [A Modern Herbal; Mrs. M. Grieve]
This agent acts upon the liver, duodenum, small intestines and colon, producing an increased activity of the bile forming function of the liver, and increasing the secretions from the glands of the intestinal tract. Large doses produce large bilious evacuations from the bowels with severe intestinal pain and colic, similar to those produced by Iris versicolor. These evacuations from the bowels are attended by a sensation of burning and are followed with tenesmus. The odor of the stools is similar to that of onions. It produces pain in both hypochondriac regions, with stitching pain in the region of the liver that extends to the right shoulder and under the right scapula. The haptic area is sensitive under palpation. Under its action the blood becomes darker in character and more fluid than is normal.
It also produces OCCIPITAL HEADACHE in which the pains are sharp and shooting in character, and are associated with tenderness of the liver, and a catarrhal condition of the duodenum and jaundice. There are sharp pains under the right shoulder blade which might remind one of Chelidonium or Bryonia. The patient often awakes about three AM with a severe occipital headache. There are bilious stools of a yellow - greenish color, their passage is attended with a sensation of burning in the anus and is followed by tenesmus.
Through the vegetative system it especially acts upon the skin, producing eczema of an erysipelatous character.
"The skin is the organ most of all affected by the drug.
All kinds of eruptions have been caused or cured by it, including scarlatina and rodent ulcer".