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Kali Nitricum acts directly upon the spinal system, paralyzing the spinal cord and the heart, arresting the action of the latter in its diastolic. It also produces an anti plastic and spoilative effect upon the blood. It acts upon the kidneys, and upon the respiratory and elimentary mucous tracts as a decided irritant, in the former producing excessive action, diuresis, the solid constituents being also, increased, and in the latter irritation, leading to congestion and inflammation.
Nitrite is poisonous, as indeed is nitrate [as it is converted to nitrite]. Nitrite bonds with the haemoglobin in the blood, as a result of which the blood loses its capacity to bond with oxygen. In particular, children can be put at risk by nitrate in, for example, water and vegetables, and nitrite in meat. Since nitrate is converted to nitrite much faster in a child's stomach, children are much more sensitive to the additive. Not only does children's blood contain less haemoglobin than that of adults, they also have a less well developed enzymatic recovery mechanism to undo the effects of nitrite.
Like the chlorate this salt is a violent irritant to the mucous membranes, causing gastro - intestinal inflammation and ulceration and catarrh of the bronchi with asthmatic breathing.Over-sensitivity to this additive can lead to stomach and intestinal disorders with intense pain, vomiting, dizziness, weakness of the muscles and irregular heartbeat. In its action on the kidneys and heart it is similar to the other salts of Potash. It passes through the kidneys with the urine, irritating and inflaming the urinary organs and in large doses produces hematuria. In moderate doses it raises the quantity of urine. In large doses it weakens the heart's action and finally arrests it.
This agent in moderate doses is a diaphoretic if the surface of the body is warm and moist and there is a free flow of blood in the skin, otherwise it acts as a diuretic.
Compendium. 1994 May;15(5):658, 660, 662 passim; quiz 667.
About dentinal hypersensitivity.
Hodosh M, Hodosh SH, Hodosh AJ.
Harvard University School of Dental Medicine, Cambridge, Massachusetts.
This article summarizes the concepts that are believed to cause dentinal hypersensitivity. It is no longer necessary and may not be feasible to obliterate dentinal tubules to obtain relief from the pain caused by dentinal hypersensitivity. In-office agents that obliterate the dentinal tubules may provide initial relief of pain, but they can impede the flow of potassium and nitrate ions toward the pulp and diminish the long-term beneficial effects seen with the routine use of potassium nitrate dentifrices. An in-office preparation that does not obliterate dentinal tubules, such as potassium nitrate gel, is recommended if potassium nitrate dentifrices are to be used for patient self-treatment. With the population living longer, dentists are challenged to maintain patients' dentition for a lifetime of comfort.