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J Ethnopharmacol. 2006 May 24;105(3):421-6. Epub 2006 Jan 30. Links
In vivo efficacy of different extracts of Edelweiss (Leontopodium alpinum Cass.) in animal models.Speroni E, Schwaiger S, Egger P, Berger AT, Cervellati R, Govoni P, Guerra MC, Stuppner H.
Department of Pharmacology, University of Bologna, Via Irnerio 48, Bologna 40126, Italy. email@example.com
Dichloromethane, methanolic and CO(2) extracts of the aerial parts and roots of Edelweiss (Leontopodium alpinum Cass.) were investigated for their anti-inflammatory and analgesic effects after oral administration. The highest activity in rat's paw edema assay was found for the lipophilic extracts of the aerial plant parts (dose 200 mg/kg), exhibiting a swelling reduction of 72% (CO(2)-extract) and 80% (DCM-extract), respectively. Histological evaluation of the treated paws showed a significant reduction of the inflammatory response in the pre-treated specimens. On the contrary in the acetic acid-induced writhing test the dichloromethane extract of the root extract exhibited more pronounced analgesic effects than the extracts of the aerial parts, suggesting a different pattern of active compounds. As far as gastrointestinal effects are concerned, oral administration of aerial parts (hDCM 200 mg/kg) to mice induces a highly significant inhibition in gastrointestinal propulsion probably related to the presence of so far unknown compounds. Moreover, the antioxidant capacity of some extracts was studied in order to establish a possible correlation with anti-inflammatory properties.
Planta Med. 2004 Jun;70(6):502-8. Links
Anti-inflammatory activity of Leontopodium alpinum and its constituents.Dobner MJ, Sosa S, Schwaiger S, Altinier G, Della Loggia R, Kaneider NC, Stuppner H.
Institut fur Pharmazie, Abteilung Pharmakognosie, Leopold-Franzens-Universitat Innsbruck, Innrain 52, 6020 Innsbruck, Austria.
The aerial parts and roots of Leontopodium alpinum Cass. (Asteraceae) were investigated for their in vivo topical anti-inflammatory activity using the inhibition of Croton oil-induced ear dermatitis in mice. For both of the plant parts, the dichloromethane extract induced a dose-dependent oedema reduction, being more active than the methanol and 70% aqueous methanol ex-tracts. Moreover, the dichloromethane extract of the aerial parts was more active than that of the roots (ID50 = 221 and 338 pg/cm2, respectively). Fatty acids make a significant contribution to the anti-oedema activity of the dichloromethane extract of the aerial parts, whereas bisabolane sesquiterpenes, tricyclic sesquiterpenes, coumarins and lignans are involved in the activity of the root extract. Two bisabolane derivatives reduced also the polymorphonuclear neutrophil leukocytes accumulation in the inflamed tissue, while a 7a-silphiperfol-5-ene type sesquiterpene and a coumarin derivative inhibited the in vitro chemotaxis of these inflammatory cells.