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Constituents: The chief constituents are a small quantity of volatile oil and a bitter principle, a glucoside called Menyanthin. The bitterness is imparted to both alcohol and water.
Z Naturforsch [C]. 2004 Jul-Aug;59(7-8):485-93. Related Articles, Links
Immunomodulating polysaccharide fractions of Menyanthes trifoliata L.
Kuduk-Jaworska J, Szpunar J, Gasiorowski K, Brokos B.
Faculty of Chemistry, Wroclaw University, 50-383 Wroclaw, Poland. email@example.com
Looking for new plant sources of immunomodulating agents polysaccharide-rich fractions (PS) from Menyanthes trifoliata L. (Menyanthaceae) have been isolated. The herb of Menyanthes trifoliata L. was sequentially extracted with water, 0.1 M NaOH, 8% CH3COOH, and 1 M NaOH. After dialysis and resolution on Biogel P-10 four homogenic (B-4, B-5, C-4, D-5) and two nonhomogenic (A-3 and D-4) PS were isolated. About 0.5% of PS over 3500 Da were found in the dry plant material. They were characterized through chemical analysis, NMR and vibrational spectroscopy. Speciation analysis of chosen metal/metaloid elements was performed and an exceptionally high concentration of Se was found in PS of a pure water extract (A-3). The biological tests on the immunomodulating influence with human blood-derived lymphocytes and granulocytes revealed that two fractions, B-4 and B-5, were strong stimulators of immune cells, whereas fractions D-5 and A-3 were found as potent suppressive and anti-inflammatory agents. The applied isolation procedures led to the separation of active compounds into stimulatory and inhibitory fractions.
J Biomol Screen. 2002 Aug;7(4):333-40. Related Articles, Links
Selective cytotoxicity evaluation in anticancer drug screening of fractionated plant extracts.
Lindholm P, Gullbo J, Claeson P, Goransson U, Johansson S, Backlund A, Larsson R, Bohlin L.
Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Uppsala, Sweden.
Chosen to reflect biodiversity in a phylogenetic sense, 100 fractionated plant extracts were screened in vitro for cytotoxicity following extraction and fractionation (polypeptide isolation). Of these 100 extracts, 30 were selected and then characterized preliminarily for antitumor potency and mode of action by testing them on two cell lines and primary cultures of human tumor cells. On the basis of cytotoxicity potency, 10 of the extracts were further characterized for anticancer activity in 10 human tumor cell lines. This final testing resulted in seven potential lead plants with superior evidence of antitumor potential: Colchicum autumnale L. (Colchicaceae), Digitalis lanata Ehrh. and Digitalis purpurea L. (Plantaginaceae), Helleborus cyclophyllus Boiss. (Ranunculaceae), Menyanthes trifoliata L. (Menyanthaceae), and Viola arvensis Murr. and Viola patrinii Ging. (Violaceae). Within a database of antitumor compounds, the activity profiles of the extracts from these seven plants were compared, by correlation analysis, with those of more than 100 other compounds, including 39 standard drugs from different classes of cytotoxic mechanisms. The activity profiles of six of these candidates were uncorrelated with those of the standard drugs, possibly indicating new pathways of drug-mediated cell death.
Yao Xue Xue Bao. 1995;30(8):621-6. Related Articles, Links
Anti-inflammatory compounds isolated from Menyanthes trifoliata L.
Huang C, Tunon H, Bohlin L.
Jiangsu Institute for Drug Control, Nanjing, People's Republic of China.