Substances & Homeopatic Remedies

Nuphar luteum

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Constituents – Vermeulen says that it contains a digitalis like glucoside, and an alkaloid that affects the smooth musculature of the intestines and the blood vessels. Animal experiments carried out in the middle of the 20th century isolated an alkaloid that puts animals into a kind of hypnotic state.
Earlier writers give the constituents as tannin, gallic acid, mucilage, starch, gum, resin, sugar, ammonia, tartaric acid.

Toxicology and pharmacology- -The root is edible, as are the seeds. When Nuphar is grown alongside lettuce seedlings, it has a toxic effect on them.
The glycosides seem to have an anaphrodisiac effect, while the tannins and gallic acid have an astringent effect. It has been marketed as part of a compound for treating deficient sexual desire, which seems contradictory.

-Constituents---The roots contain tannin, gallic acid and mucilage, starch, gum, resin, sugar, ammonia, tartaric acid, fecula, etc.

The EUROPEAN YELLOW POND-LILY (Nuphar Advena or Nuphar luteum - Spatterdock or Frog-lily) may be used as a substitute. It contains much nuphar-tannic acid

J Nat Prod. 2003 Apr;66(4):548-50.   
Phenolic compounds from Nymphaea odorata.
Zhang Z, ElSohly HN, Li XC, Khan SI, Broedel SE Jr, Raulli RE, Cihlar RL, Burandt C, Walker LA.
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, and Department of Pharmacology, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA.

Assay-guided fractionation of the ethanol extract of Nymphaea odorata resulted in the identification of two lignans, one new (1) and one known (2), together with six known flavonol glycosides (3-8). The structures of 1-8 were established by spectroscopic analysis as nymphaeoside A (1), icariside E(4) (2), kaempferol 3-O-alpha-l-rhamnopyranoside (afzelin, 3), quercetin 3-O-alpha-l-rhamnopyranoside (4), myricetin 3-O-alpha-l-rhamnopyranoside (myricitrin, 5), quercetin 3-O-(6' '-O-acetyl)-beta-d-galactopyranoside (6), myricetin 3-O-beta-d-galactopyranoside (7), and myricetin 3-O-(6' '-O-acetyl)-beta-d-galactopyranoside (8). Compounds 3, 4, and 7 showed marginal inhibitory effect against fatty acid synthase with IC(50) values of 45, 50, and 25 microg/mL, respectively.

Bull Environ Contam Toxicol. 1983 May;30(5):575-81.  
Seasonal variation in the accumulation of radionuclides of the uranium series by yellow pond-lily (Nuphar lutea).
Mahon DC, Mathewes RW.