Substances & Homeopatic Remedies

Prunus spinosa

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The Prunusgenus contains prussic acid, mainly in the seeds in about o.16%.
Toxicologic properties are agitation, forced respiration, headaches,  respiratory and cardiac arrest.

Emerg Med J. 2004 May;21(3):392. Related Articles, Links  
Blackthorn injury: a report of three interesting cases.
Sharma H, Meredith AD.
Department of Trauma and Orthopaedics, Southern General Hospital, Glasgow, UK. <>

Blackthorn (Prunus spinosus), a member of Rosacea family is well known for causing infections and tissue reactions of synovial structures. Three interesting cases of cystic blackthorn granuloma, blackthorn synovitis with digital nerve entrapment, and multiple blackthorn syndrome are presented. Removal of foreign body fragments and surrounding reactive tissues resulted in an uneventful recovery with full return of joint and tendon functions.

Acta Orthop Scand. 1985 Aug;56(4):342-3. Related Articles, Links  
A case of blackthorn synovitis.
Stromqvist B, Edlund E, Lidgren L.

A seven-year-old boy fell against a blackthorn bush and found that thorns had penetrated the skin over the left knee. Aseptic synovitis developed with repeated febrile episodes. With the suspicion of septic arthritis, the patient was treated with antibiotics on repeated occasions, two negative joint aspirations and a knee joint exploration were performed. Three months after the injury the correct diagnosis was made at a second arthrotomy when an intra-articular thorn was removed and synovectomy carried out, after which healing was uneventful.

Ann Rheum Dis. 1983 Jun;42(3):285-91. Related Articles, Links  
Activation of the alternative pathway of complement by monosodium urate monohydrate crystals and other inflammatory particles.
Doherty M, Whicher JT, Dieppe PA.

Activation of serum C3 by monosodium urate monohydrate (MSU) crystals and other particles was determined by immunofixation following electrophoretic separation of C3 and its activation products. Densitometry allowed quantitation of results. MSU, hydroxyapatite, brushite, and calcium pyrophosphate dihydrate crystals split C3 under conditions which demonstrate activation via the alternative pathway (AP). Quantitatively similar results were obtained in immunoglobulin deficient serum. Activation was crystal specific and was reduced by heating, grinding, sonication, and aging of crystals. Other inflammatory particles (e.g., blackthorn) activated C3 via the AP: noninflammatory particles (e.g., diamond) caused insignificant activation. It is suggested that particle-induced activation of the alternative pathway of complement may be important in the initiation of crystal-induced synovitis.

Br Med J (Clin Res Ed). 1981 Jan 31;282(6261):361-2. Related Articles, Links  
Monoarthritis from blackthorn injury: a novel means of diagnosis.
Blake DR, Bacon PA, Scott CA, Potter AR.

Acta Pol Pharm. 2001 Nov-Dec;58(6):459-62. Related Articles, Links  
Triterpenes and sterols in the flowers and leaves of Prunus spinosa L. (Rosaceae).
Wolbis M, Olszewska M, Wesolowski WJ.
Department of Pharmacognosy, Institute of Technology and Chemistry of Drugs, Medical University of Lodz, Poland.

From the flowers of Prunus spinosa L. a mixture of alpha- and beta-amyrine, a mixture of ursolic and oleanolic acids, ursolic acid, a mixture of beta-sitosterol, gamma-sitosterol and stigmasterol and beta-sitosterol 3-O-beta-D-glucopyranoside were isolated. Their structure was determined by spectroscopic methods (GC/MS, IR, 1H and 13C NMR). Chromatographic methods (GC, HPLC, TLC) were employed to determine the presence of the listed compounds in the leaves. Also, the content of beta-sitosterol, ursolic and oleanolic acids in the leaves and flowers of blackthorn was determined by GC/MSD method.

Fitoterapia (Firenzuoli)
Prunus spinosa:  depressione  e  impotenza (sempre su base psicogena).

Fitoterapia  (Negri)
Prunus spinosa o prùgnolo o prugno selvatico.
Pianta molto comune nei boschi e nelle siepi di tutta Italia, continentale o insulare, dal mare al piano montano.
I fiori compaiono fra MAGGIO e AGOSTO, contengono tracce di amigdalina, sono usati nella tradizione popolare come lassativi e blandi diuretici.
La corteccia ricca di sostanze tanniniche ha proprietà astringenti.
Nei frutti vi sono: tannini, acidi organici, resina, zucchero, una sostanza colorante propria, una sostanza fluorescente (forse affine alla esculina dell'ippocastano).
Uno sciroppo a base di estratto del frutto era stato associato allo ioduro di potassio per mascherarne il sapore.
Avvelenamenti acuti ++ per ingestione di grandi quantità di semi di mandorle (amare): asprezza e dolore alle fauci, salivazione abbondante, nausea, vomito, vertigini, senso di ambascia, accelerazione del polso, tachicardia, sudirazione fredda, cianosi, respirazione difficile, perdita di conoscenza e morte.