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Frans Vermeulen Prisma 2002 pp 1149 - 56
Ruta is toxic. Ingestion causes stomach pain, vomiting, exhaustion, confusion, and convulsions; large amounts may be fatal. The plant is irritant and vesicant, esp. in the heat of summer; handling of the flowers and fruit has produced erythema, burning, itching, and vesication. Much of this activity, however, is dissipated by drying.
... the genus contains quinoline alkaloids, essential oils, coumarins, and limonoids. ... Over 110 chemicals have been found in Ruta graveolens, four of which are listed with either abortifacient or antifertility activity. Duke lists the quinoline alkaloids arborinine, graveolinine and skimmianine as abortion-producing and chalepensin as having antifertilty activity. ... Taken internally, rue also can provoke photodermatitis ...