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(Planta Med. 1993 Jun;59(3):246-9)
Antineoplastic and antiviral activities of some cyclolignans.
San Feliciano A, Gordaliza M, Miguel del Corral JM, Castro MA, Garcia-Gravalos MD, Ruiz-Lazaro P.
Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Salamanca, Spain.
Nineteen cyclolignans of varied structures, most of them isolated from Juniperus sabina leaves, were evaluated for their antineoplastic and antiviral activities. They were subjected to screening against P-388 murine leukemia, A-549 human lung carcinoma, and HT-29 colon carcinoma, while the antiviral assays were performed on herpes simplex virus type 1 infecting fibroblasts of monkey kidney (HSV-1/CV-1) and on vesicular stomatitis virus infecting fibroblasts of hamster kidney (VSV/BHK). A number of substances were active in both types of assays at concentrations below 1 microgram/ml; deoxypodophyllotoxin and beta-peltatin A methyl ether being the most potent compounds in all cases, with IC50 values in the range 2.5-4 ng/ml for the three neoplastic systems.
(Planta Med. 1989 Apr;55(2):144-6)
Teratological evaluation of Juniperus sabina essential oil in mice.
Pages N, Fournier G, Chamorro G, Salazar M, Paris M, Boudene C.
Juniperus sabina essential oil was evaluated for its fetotoxic potential on mice. Pregnant dams were injected s.c. (15-45 or 135 mg essential oil/kg body weight) on days 6 to 15 of gestation. They were killed and the uterine contents were examined on day 19 of pregnancy. The fetuses were removed for examination. The dams of the two higher treated groups showed a significant weight loss as compared to controls. An hepatotoxicity was observed among females that resorbed their whole litter, thus indicating a greater susceptibility towards Juniperus sabina essential oil during pregnancy. The essential oil induced, in the three treated groups, an embryotoxicity as manifested by a statistically significant increase in the number of affected litters; but no fetotoxicity.