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Care must be exercised in the use of this drug as it is often destructive of kidney tissue. Most of the drug is excreted unchanged through the urine; if salicyluric acid is removed, urine becomes at once putrid; if not, it remains fresh for above a week: hence its use to preserve food, but this is often the cause of allergic reaction. Headache, delirium, visions, and even death have not infrequently been induced by doses thought to be medicinal. An excesive use of the drug can cause heart complications. The heart is at first stimulated and the pulse quick, soft and compressible, but it soon becomes slow and feeble from dilatation and weakness of the heart. The blood - pressure is first raised and then lowered from stimulation followed by depression of the vasomotor centre. Metabolism is considerably modified, as shown by the fact that there is an increase of 10 to 12 per cent. in the nitrogen of the urine and of 30 to 45 per cent. in the uric acid. It irritates mucous membranes (see ulceration) and may cause vomiting when given in large doses on an empty stomach. Large therapeutic doses produce ringing in the ears, Menière's disease (auditory nerve vertigo), deafness with tinnitus and purpura haemorrhagica. In very large doses it may produce depression of the central nervous system, rarely convulsions. Haemorrhagic tendencies are very pronounced in regard to nose, gums, and stomach.