Substances & Homeopatic Remedies

Scrophularia nodosa

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Phytother Res. 2002 Feb;16(1):33-5.
Wound healing activity of acylated iridoid glycosides from Scrophularia nodosa.
Stevenson PC, Simmonds MS, Sampson J, Houghton PJ, Grice P.
Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, TW9 3DS, UK.

Three acylated iridoid glycosides (E)-6-O-(2", 4"-diacetyl-3" -O-p-methoxycinnamoyl)-alpha-L-rhamnopyranosyl catalpol (scopolioside A) (1), (E)-6-O-(2"-acetyl-3", 4"-di-O,O-p-methoxycinnamoyl)-alpha-L-rhamnopyranosyl catalpol (scrophuloside A(4)) (2) and (E)-6-O-(2",3"-diacetyl-4"-O-p-methoxycinnamoyl)-alpha-L-rhamnopyranosyl catalpol (scrovalentinoside) (3) have been isolated from the dried seed pods of Scrophularia nodosa by HPLC. Their structures were determined by 1D and 2D NMR, UV/Vis and mass spectroscopy and by comparison with published data. All three compounds were shown in vitro to stimulate the growth of human dermal fibroblasts. The effect was negatively dose-dependent for 2 and 3 for which fibroblast growth stimulation was highest at 0.78 microg/mL but was not significantly different from the control at 100 microg/mL. The presence of these compounds in the mature seed pods may explain the ethnobotanical use of this plant in Europe for healing wounds


J Nat Prod. 1999 Aug;62(8):1079-84.
Acylated iridoid and phenylethanoid glycosides from the aerial parts of Scrophularia nodosa.
Miyase T, Mimatsu A.
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. miyase@ys7.u-shizuoka-ken.ac.jp

From the aerial parts of Scrophularia nodosa L. (Scrophulariaceae), eighteen acylated iridoid glycosides and nine phenylethanoid glycosides were isolated. The structures of eight new iridoid and two new phenylethanoid glycosides were elucidated on the basis of chemical and spectroscopic evidences.