Substances & Homeopatic Remedies

Sequoia sempervirens

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The chemical composition of the tree itself is apparently distasteful or even poisonous to normal tree pests like termites and ants. That is why it was used as the first layer of boards in a wall, because termites and carpenter ants won't burrow into it. In the 30's to the early 60's redwood was used as a separator between the plates of electrolytic (auto, truck and airplane) batteries. The wood could withstand the battery acid and still retain its shape.
Toxicity: Working with redwood may cause allergic reactions (4,10&16).

J Nat Prod. 2001 Oct;64(10):1350-3.  
Sequoiatones C-f, constituents of the redwood endophyte Aspergillus parasiticus.
Stierle AA, Stierle DB, Bugni T.
Department of Chemistry and Geochemistry, Montana Tech of the University of Montana, Butte, MT 59701, USA.

Aspergillus parasiticus, a fungal isolate from a coast redwood tree (Sequoia sempervirens), has been shown to produce four new compounds, sequoiatones C-F (1-4). The structures of these compounds, all of which are cytotoxic to brine shrimp, were deduced by spectral analysis.

J Org Chem. 1999 Jul 23;64(15):5479-5484.  
Sequoiatones A and B: Novel Antitumor Metabolites Isolated from a Redwood Endophyte.
Stierle AA, Stierle DB, Bugni T.
Department of Chemistry and Geochemistry, Montana Tech of the University of Montana,Butte, Montana 59701.

Sequoiatones A and B were isolated from the fungus Aspergillus parasiticus, an endophytic fungus of the coast redwood, Sequoia sempervirens. The compounds were isolated from the methanol extract of the mycelial mat of the fungus when grown in liquid culture for 21 days. The compounds were isolated because of their brine shrimp lethality, which served as an excellent guide for chromatographic purification. Full details of the isolation and characterization of sequoiatones A and B are provided herein, along with the test results from the NCI human tumor 60 cell-line screen.

Bioorg Med Chem Lett. 2005 Apr 15;15(8):2019-21.  
Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens.
Son KH, Oh HM, Choi SK, Han DC, Kwon BM.
Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology in Korea, 52 Uendong Yoosunggu Taejeon, 305-600 Republic of Korea.

A new abietane, namely, 20-hydroxyferruginol (1), together with known ferruginol (2), 18-hydroxyferruginol (3), sugiol (4), and 6alpha-hydroxysugiol (5), were isolated from the cones of Sequoia sempervirens. Their structures were elucidated through spectral data. Compounds 1 and 5 strongly inhibited colon, lung, and breast human tumors and oncogene transformed cells with GI(50) 2-5 microg/mL.