Substances & Homeopatic Remedies

Staphisagria

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Constuituents:
Delphinum, Delphinoidine, Delphisine, Staphysagrine,  fixed oil, volatile oil, malic acid, mucilage.
Constituents---The chief constituents of Stavesacre seeds are from 20 to 25 per cent of alkaloidal matter, which consists chiefly of the bitter, acrid, crystalline, alkaloid Delphinine, an irritant poison, and a second crystalline alkaloid named Delphisine, and the amorphous alkaloid Delphinoidine. Less important are staphisagroine, of which traces only are present, and staphisagrine, which appears to be a mixture of the first three elements.

J Nat Prod. 2011 Apr 25;74(4):744-50. Epub 2011 Apr 5.
In vitro and in vivo trypanocidal activity of flavonoids from Delphinium staphisagria against Chagas disease.
Marín C, Ramírez-Macías I, López-Céspedes A, Olmo F, Villegas N, Díaz JG, Rosales MJ, Gutiérrez-Sánchez R, Sánchez-Moreno M.
Department of Parasitology, University of Granada, Severo Ochoa s/n, E-18071 Granada, Spain.
Abstract
The in vitro and in vivo trypanocidal activities of nine flavonoids (1-9) isolated from the aerial parts of Delphinium staphisagria have been studied in both the acute and chronic phases of Chagas disease. The antiproliferative activity of these substances against Trypanosoma cruzi (epimastigote, amastigote, and trypomastigote forms) in some cases exhibited more potent antitrypanosomatid activity and lower toxicity than the reference drug, benznidazole. Studies in vitro using ultrastructural analysis together with metabolism-excretion studies were also performed in order to identify the possible action mechanism of the compounds tested. Alterations mainly at the level of the mitochondria may explain metabolic changes in succinate and acetate production, perhaps due to the disturbance of the enzymes involved in sugar metabolism within the mitochondrion. In vivo studies provided results consistent with those observed in vitro. No signs of toxicity were detected in mice treated with the flavonoids tested, and the parasitic charge was significantly lower than in the control assay with benznidazole. The effects of these compounds were also demonstrated with the change in the anti-T. cruzi antibody levels during the chronic stage.