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In large doses it is emetic and purgative causing a disagreeable, peculiar, burning sensation in the stomach or alimentary canal with considerable prostration of the system; in smaller doses it is an excellent alterative, and influences the secretory functions; it has almost a specific action in the different forms of primary and secondary syphilis, also in skin diseases, scrofula and hepatic affections, acting with most successful results. The fluid extract combined with oils of anise or caraway, proves very beneficial in chronic bronchitis and laryngitis. Some pieces of fresh root chewed daily have permanently and effectually cured these troubles, it is also useful for leucorrhoea. The oil is too acrid for internal use uncombined with saccharine or mucilaginous substance, for internal use the fluid extract or syrup is sufficiently efficacious. As an external stimulating application in most cases the oil will be found very valuable. For croup 1 drop on the tongue three or four times daily, has been found successful for severe attacks. The dried root is said to be inferior in strength to the fresh one, but some chemists consider it more powerful. It may be given either alone or combined with sarsaparilla and other alteratives. It acts reflexly as a sialagogue and expectorant. It is often given for syphilitic complaints in place of mercury.
Historically, Stillingia was once thought to be a reliable cure for syphilis (which it is not), the decoction having been used to treat continuing pain and ulceration after mercurial treatment. Stillingia Root often occurred as a mixture of entire, cut, and as partially cut pieces. American Eclectic physicians in the nineteenth century used it as a treatment for tuberculosis and cancer, as well as other conditions for which an alterative could be recommended. Stillingia Root has the nature of an alterative and is beneficial in disease states that affect the skin, i.e., psoriasis and eczema. Stillingia, though extremely beneficial in blood purification, is best used in small amounts. The primary chemical constituents of this herb include tannins, volatile oil, acrid resin (sylvacrol), acrid fixed oil, starch, calcium oxalate, cyanogenic glycosides, gum, and other resins. Stillingia Root is of value in the treatment of chronic skin conditions such as eczema and psoriasis, and is specifically indicated where there is lymphatic involvement. Treatment is likely to be fairly long-term. This herb is also used to treat bronchial congestion and laryngitis, especially when accompanied by loss of voice (laryngismus stridulus). It may also be used to treat croup when the cough is harsh (the herb helps promote the flow of saliva). It will help to relieve constipation and, as an astringent, it is particularly of benefit for hemorrhoids. Stillingia also alleviates any general fluids dyscrasia (abnormal or pathological condition) within the bone tissue or skeletal structure that leads to conditions involving osteomalacia (skeletal deformities), osteomyelitis (infectious pathogenic bone disorders), and osteoporosis (brittle bone conditions) or spinal degeneration.