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Thioproperazine or 7843 R.P. is the bi-methane sulphonate of dimethyl-sulphamoyl 3 [(methyl 4'-piperazine)-3'-propyl] 10 phenothiazine.
Minerals; Organic Compounds; Acyclic Carbon Compounds; More Substances of Organic Origin; Synthetic Drugs
Clerbaux: annales homeop. francaise 1973-1977
Description of the substance
Phenothiazines (FEE-noe-THYE-a-zeens) are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in s...
Action And Clinical Pharmacology: Thioproperazine is a potent neuroleptic with antipsychotic properties.
Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects. It is virtually without antiserotonin and hypotensive action and has no antihistaminic property.
from Julian's New Remedies:
Thioproperazine is the bi-metane sulphonate of dimetyl-sulphamoyl.3[(methyl4'piperazine)-3'-propyl]
Physical properties: Thiop.is a fine, yellowish-white slightly hygroscopic powder. Its fusion point is about 225C
Toxicology: in mice the acute toxicity of Thiop. is smaller by hypodermic injection and taken orally, then the toxicity of chlorpromazine; it is nearly equivalent to intravenous and intraperitonal injections.
General properties: central activity, anti-apomorphine, cataleptic and sedative activity.
Thiop. has a very slight hypotensive activity.
If given in a dose of 1mg/kg by intravenous injection the effects of adrenalin are only reduced.
Its shows no antihistaminic activity ( Bovet and Staub test). Its spasmolytic activity is about twenty times less than Lispamol.