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Veratrum album, or white hellebore, an herbal medicine described by Hippocrates before 400 BC, contains the alkaloids cyclopamine and jervine, which are teratogens capable of causing cyclopia (holoprosencephaly). Students of teratology have raised the possibility of a link between this developmental deformity and the myth for which it was named.
(In the Theogony by Hesiod, the Cyclopes – Arges, Brontes, and Steropes were the primordial sons of Uranus (Sky) and Gaia (Earth) and brothers of the Hecatonchires. They were giants with a single eye in the middle of their forehead and a foul disposition. According to Hesiod, they were strong, stubborn, and "abrupt of emotion". Collectively they eventually became synonyms for brute strength and power, and their name was invoked in connection with massive masonry).